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Study Design The researchers cultured 240 human hair follicles from 10 healthy volunteers ex vivo, meaning outside the body in a laboratory culture environment

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This study found that CEF treatments (50, 100, and 200 mg/kg) 15 min before each morphine injection twice daily for 7 days attenuated morphine-induced tolerance, and this effect was abolished following the administration of a GLT-1 inhibitor, dihydrokainate